PRIMPOL Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

CC111_HUMAN antibody; CCDC111 antibody; Coiled coil domain containing 111 antibody; Coiled-coil domain-containing protein 111 antibody; DNA-directed primase/polymerase protein antibody; MYP22 antibody; Primase and polymerase (DNA directed) antibody; PRIMPOL antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96LW4

Immunogen

Recombinant Human DNA-directed primase/polymerase protein (305-537AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PRIMPOL

Research Areas

Epigenetics and Nuclear Signaling