Presenilin 1(Phospho Ser357) Polyclonal Antibody

Ab type

Primary antibody

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human PSEN1 around the phosphorylation site of Ser357. AA range:323-372

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

52668

synonyms

Presenilin-1; PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182