PRA1 Antibody

Size

100ul

Clone Number

Aliases

PRA1 antibody; FBP1 antibody; CAALFM_C406980WA antibody; CaO19.10623 antibody; CaO19.3111 antibody; pH-regulated antigen PRA1 antibody; 58 kDa fibrinogen-binding mannoprotein antibody

Immunogen Species

Candida albicans

UniProt ID

P87020

Immunogen

Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)

Raised in

Rabbit

Species Reactivity

Candida albicans

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PRA1

Research Areas

N/A