PPP1CA Antibody

Size

100ug

Clone Number

Aliases

Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit antibody; Catalytic subunit antibody; EC 3.1.3.16 antibody; MGC15877 antibody; MGC1674 antibody; PP 1A antibody; PP-1A antibody; PP1A antibody; PP1A_HUMAN antibody; PP1alpha antibody; PP2C ALPHA antibody; PP2CA antibody; Ppp1ca antibody; Protein Phosphatase 2C Alpha Isoform antibody; Serine threonine protein phosphatase PP1 alpha catalytic subunit antibody; Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1 antibody; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P62136

Immunogen

Recombinant Human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit protein (192-330AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the \'Ser-418\' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PPP1CA

Research Areas

Cancer; Metabolism; Signal transduction