PPM1A Antibody

Size

100ul

Clone Number

Aliases

Protein phosphatase 2C isoform alpha antibody; EC 3.1.3.16 antibody; FLJ42306 antibody; IA antibody; MGC9201 antibody; Mpp alpha antibody; PP2C alpha antibody; PP2C-alpha antibody; PP2CA antibody; PP2Calpha antibody; PPM 1A antibody; PPM1A antibody; PPM1A_HUMAN antibody; PPPM1A antibody; Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform antibody; Protein phosphatase 1A antibody; Protein phosphatase 1A magnesium dependent alpha antibody; Protein phosphatase 2C alpha antibody; Protein phosphatase 2C alpha isoform antibody; Protein phosphatase 2C isoform alpha antibody; Protein phosphatase IA antibody; Protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P35813

Immunogen

Recombinant Human Protein phosphatase 1A protein (1-382AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PPM1A

Research Areas

Signal transduction