PPIG Polyclonal Antibody

Ab type

Primary antibody

Background

Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.,enzyme regulation:Cyclosporin A (CsA)-sensitive.,PPIases accelerate the folding of proteins.,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the cyclophilin-type PPIase family.,Contains 1 PPIase cyclophilin-type domain.,subcellular location:Colocalizes with RNA splicing factors at nuclear speckles.,subunit:Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.,tissue specificity:Ubiquitous.,

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human protein . at AA range: 290-370

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Peptidyl-prolyl cis-trans isomerase G ;PPIase G;Peptidyl-prolyl isomerase G;EC 5.2.1.8;CASP10;Clk-associating RS-cyclophilin;CARS-Cyp;CARS-cyclophilin;SR-cyclophilin;SR-cyp;SRcyp;C