PPID Antibody

Size

100ul

Clone Number

Aliases

40 kDa peptidyl-prolyl cis-trans isomerase antibody; 40 kDa peptidyl-prolyl cis-trans isomerase D antibody; Cyclophilin related protein antibody; Cyclophilin-40 antibody; Cyclophilin-related protein antibody; CYP-40 antibody; CYP40 antibody; CYPD antibody; Estrogen receptor-binding cyclophilin antibody; Peptidyl-prolyl cis-trans isomerase D antibody; Peptidylprolyl isomerase D antibody; PPIase D antibody; Ppid antibody; PPID_HUMAN antibody; Rotamase antibody; Rotamase D antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q08752

Immunogen

Recombinant Human Peptidyl-prolyl cis-trans isomerase D protein (161-370AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PPID

Research Areas

Immunology