PPARGC1A Monoclonal Antibody

Size

Clone Number

Aliases

PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)

Immunogen Species

Human

UniProt ID

Q9UBK2

Immunogen

Purified recombinant fragment of human PGC-1alpha expressed in E. Coli

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,WB;Recommended dilution:WB:1:500-1:5000

Background

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPAR gamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. "

Clonality

Monoclonal

Isotype

IgG1

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?C.Stable for 12 months from date of receipt

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PPARGC1A

Research Areas

Epigenetics and Nuclear Signaling;Cancer?Cardiovascular;Metabolism