POT1 Antibody

Size

100ug

Clone Number

Aliases

DKFZP586D211 antibody; hPot 1 antibody; hPot1 antibody; POT 1 antibody; POT1 antibody; POT1 like telomere end-binding protein antibody; POT1 protection of telomeres 1 homolog antibody; POT1-like telomere end-binding protein antibody; POTE1_HUMAN antibody; Protection of telomeres 1 antibody; Protection of telomeres 1 homolog (S. pombe) antibody; Protection of telomeres protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NUX5

Immunogen

Recombinant Human Protection of telomeres protein 1 protein (250-432AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5\'-TTAGGG-3\' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5\'-TAGGGTTAG-3\' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3\'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

POT1

Research Areas

Epigenetics and Nuclear Signaling; Cancer