POLK Antibody

Size

100ug

Clone Number

Aliases

DinB homolog 1 (E. coli) antibody; DINB protein antibody; DINB1 antibody; DINP antibody; DNA damage inducible protein b antibody; DNA polymerase kappa antibody; Polk antibody; POLK_HUMAN antibody; POLQ antibody; Polymerase (DNA directed) kappa antibody; polymerase, DNA, kappa antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UBT6

Immunogen

Recombinant Human DNA polymerase kappa protein (227-337AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3\\\'-5\\\' proofreading exonuclease activity. Forms a Schiff base with 5\\\'-deoxyribose phosphate at abasic sites, but does not have lyase activity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

POLK

Research Areas

Epigenetics and Nuclear Signaling