POFUT2 Antibody

Size

100ug

Clone Number

Aliases

POFUT2 antibody; C21orf80 antibody; FUT13 antibody; KIAA0958 antibody; GDP-fucose protein O-fucosyltransferase 2 antibody; EC 2.4.1.221 antibody; Peptide-O-fucosyltransferase 2 antibody; O-FucT-2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y2G5

Immunogen

Recombinant Human GDP-fucose protein O-fucosyltransferase 2 protein (125-271AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

POFUT2

Research Areas

Tags & Cell Markers; Metabolism; Signal transduction