PLEKHO1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

C-Jun-binding protein antibody; Casein kinase 2-interacting protein 1 antibody; CK2 interacting protein 1 antibody; CK2 interacting protein 1 HQ0024c protein antibody; CK2-interacting protein 1 antibody; CKIP 1 antibody; CKIP-1 antibody; CKIP1 antibody; JBP antibody; OC120 antibody; Osteoclast maturation associated gene 120 protein antibody; Osteoclast maturation-associated gene 120 protein antibody; PH domain-containing family O member 1 antibody; PKHO1_HUMAN antibody; Pleckstrin homology domain containing family O member 1 antibody; Pleckstrin homology domain-containing family O member 1 antibody; PLEKHO1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q53GL0

Immunogen

Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PLEKHO1

Research Areas

Signal transduction