PLB(Phospho Ser16/T17) Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. AA range:1-50

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

6109

synonyms

Cardiac phospholamban; PLN; PLB; Cardiac phospholamban; PLB