PKR Polyclonal Antibody

Ab type

Primary antibody

Background

Eukaryotic translation initiation factor 2 alpha kinase 2 encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of eukaryotic translation initiation factor 2 alpha kinase 2 can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. Eukaryotic translation initiation factor 2 alpha kinase 2 encoded by EIF2AK2 is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for EIF2AK2.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human PKR. AA range:413-462

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

62094

synonyms

EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-depe