PKD1 Antibody

Size

100ug

Clone Number

Aliases

Autosomal dominant polycystic kidney disease 1 protein antibody; Autosomal dominant polycystic kidney disease protein 1 antibody; nPKC-D1 antibody; nPKC-mu antibody; OTTHUMP00000208669 antibody; OTTHUMP00000208670 antibody; PBP antibody; Pc-1 antibody; PKD antibody; Pkd1 antibody; PKD1_HUMAN antibody; Polycystic Kidney Disease 1 antibody; polycystic kidney disease-associated protein antibody; Polycystin 1 Precursor antibody; Polycystin-1 antibody; Protein kinase C mu type antibody; Protein kinase D antibody; Serine/threonine-protein kinase D1 antibody; transient receptor potential cation channel; subfamily P; member 1 antibody; TRPP1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P98161

Immunogen

Recombinant Human Polycystin-1 protein (615-753AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500

Background

Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PKD1

Research Areas

Cancer; Metabolism; Signal transduction