PKA C(Phospho-Thr197) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes one of the catalytic subunits of protein kinase A| which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits| in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes| including differentiation| proliferation| and apoptosis. Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human PKA C (Thr197)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

PKA C ;Thr197 ; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; EC 2.7.11.11