PKA alpha cat(Phospho Ser338) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human PKAα cat (phospho Ser338)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

40590

synonyms

cAMP-dependent protein kinase catalytic subunit alpha; PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha