PIWIL1 Antibody

Size

100ul

Clone Number

Aliases

HIWI antibody; MIWI antibody; Piwi (Drosophila) like 1 antibody; PIWI antibody; Piwi homolog antibody; Piwi like 1 (drosophila) antibody; Piwi like 1 antibody; Piwi-like protein 1 antibody; PIWIL1 antibody; PIWL1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96J94

Immunogen

Recombinant Human Piwi-like protein 1 protein (390-690AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator (PubMed:12037681, PubMed:16287078).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PIWIL1

Research Areas

Epigenetics and Nuclear Signaling