PITRM1 Antibody

Size

100ul

Clone Number

Aliases

hMP1 antibody; hPreP antibody; KIAA1104 antibody; Metalloprotease 1 antibody; MGC138192 antibody; MGC141929 antibody; mitochondrial antibody; MP1 antibody; Pitrilysin metallopeptidase 1 antibody; Pitrilysin metalloproteinase 1 antibody; PITRM 1 antibody; PITRM1 antibody; PreP antibody; PreP peptidasome antibody; PREP_HUMAN antibody; Presequence protease antibody; Presequence protease mitochondrial antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q5JRX3

Immunogen

Recombinant Human Presequence protease, mitochondrial protein (758-1037AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PITRM1

Research Areas

Cell biology