PIK3C3 Antibody

Size

100ug

Clone Number

Aliases

hVps34 antibody; MGC61518 antibody; Phosphatidylinositol 3 kinase catalytic subunit type 3 antibody; Phosphatidylinositol 3 kinase class 3 antibody; Phosphatidylinositol 3 kinase p100 subunit antibody; Phosphatidylinositol 3-kinase catalytic subunit type 3 antibody; Phosphatidylinositol 3-kinase p100 subunit antibody; Phosphoinositide 3 kinase class 3 antibody; Phosphoinositide-3-kinase class 3 antibody; PI3 kinase type 3 antibody; PI3-kinase type 3 antibody; PI3K type 3 antibody; Pik3c3 antibody; PK3C3_HUMAN antibody; PtdIns 3 kinase type 3 antibody; PtdIns-3-kinase type 3 antibody; Vps 34 antibody; Vps34 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8NEB9

Immunogen

Recombinant Human Phosphatidylinositol 3-kinase catalytic subunit type 3 protein (700-850AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PIK3C3

Research Areas

Immunology; Metabolism; Signal transduction