PIEZO1 Antibody

Size

100ul

Clone Number

Aliases

DHS antibody; Fam38a antibody; Family with sequence similarity 38 member A antibody; KIAA0233 antibody; Membrane protein induced by beta-amyloid treatment antibody; Mib antibody; PIEZ1_HUMAN antibody; Piezo-type mechanosensitive ion channel component 1 antibody; PIEZO1 antibody; Protein FAM38A antibody; Protein FAM38B antibody; Protein PIEZO1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92508

Immunogen

Recombinant Human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PIEZO1

Research Areas

Tags & Cell Markers