PIAS1 Antibody

Size

100ul

Clone Number

Aliases

AR interacting protein antibody; DDXBP1 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 antibody; DEAD/H box binding protein 1 antibody; DEAD/H box-binding protein 1 antibody; E3 SUMO-protein ligase PIAS1 antibody; GBP antibody; Gu binding protein antibody; Gu-binding protein antibody; GU/RH-II antibody; Pias1 antibody; PIAS1_HUMAN antibody; Protein inhibitor of activated STAT protein 1 antibody; Protein inhibitor of activated STAT; 1 antibody; RNA helicase II binding protein antibody; RNA helicase II-binding protein antibody; Zinc finger; MIZ-type containing 3 antibody; ZMIZ3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75925

Immunogen

Recombinant Human E3 SUMO-protein ligase PIAS1 protein (422-651AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at\\\'Lys-65\\\' and \\\'Lys-160\\\') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PIAS1

Research Areas

Epigenetics and Nuclear Signaling