Phospho-Catenin-Beta (S552) Polyclonal Antibody

Ab type

Primary antibody

Background

Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

Reactivity

Human;mouse;rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Catenin-β (phospho Ser552)

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

85497

synonyms

CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin