Phospho-AR-Beta2 (S355/S356) Polyclonal Antibody

Ab type

Primary antibody

Background

ADRB2 encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. ADRB2 is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

Reactivity

Human;mouse;rat;monkey

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor B2 around the phosphorylation site of Ser355 and Ser356. AA range:331-380

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

46557

synonyms

ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor