PHF21A Antibody

Size

100ug

Clone Number

Aliases

BHC80a antibody; BM-006 antibody; BRAF35-HDAC complex protein BHC80 antibody; BRAF35/HDAC2 complex (80 kDa) antibody; KIAA1696 antibody; PF21A_HUMAN antibody; PHD finger protein 21A antibody; PHF21A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96BD5

Immunogen

Recombinant Human PHD finger protein 21A protein (312-487AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of \\\'Lys-4\\\' of histone H3 in vitro, suggesting a role in demethylation regulation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PHF21A

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience