Perforin 1 Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

61377

synonyms

Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)