PDK3 Antibody

Size

100ul

Clone Number

Aliases

[Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial antibody; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 antibody; CMTX6 antibody; GS1-358P8.4 antibody; mitochondrial antibody; PDK3 antibody; PDK3_HUMAN antibody; Pyruvate dehydrogenase kinase isoenzyme 3 antibody; Pyruvate dehydrogenase kinase isoform 3 antibody; Pyruvate dehydrogenase kinase isozyme 3 antibody; Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15120

Immunogen

Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial protein (137-406AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PDK3

Research Areas

Metabolism; Signal transduction