PDK1(Phospho Tyr9) Polyclonal Antibody

Ab type

Primary antibody

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,Belongs to the protein kinase superfamily.,Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,Contains 1 PH domain.,Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human PDK1 around the phosphorylation site of Tyr9. AA range:1-50

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

63152

synonyms

3-phosphoinositide-dependent protein kinase 1; PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1