PDK1(Phospho Ser241) Polyclonal Antibody

Ab type

Primary antibody

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|Phosphorylates and activates not only PKB/AKT| but also PKA| PKC-zeta| RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.|PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241| leading to its own activation.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.|Contains 1 PH domain.|Contains 1 protein kinase domain.|subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.|subunit:Interacts with TUSC4.|tissue specificity:Appears to be expressed ubiquitously.|

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human PDK1 around the phosphorylation site of Ser241. AA range:210-259

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

63152

synonyms

3-phosphoinositide-dependent protein kinase 1; PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1