PCNA Monoclonal Antibody(12D10)

Ab type

Primary antibody

Background

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Reactivity

Human,Rat,Mouse

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Immunogen

Synthetic Peptide of PCNA

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

28769

synonyms

PCNA; Proliferating cell nuclear antigen; PCNA; Cyclin