PBX1 Antibody

Size

100ug

Clone Number

Aliases

DKFZp686B09108 antibody; Homeo box protein PBX1 antibody; Homeo box protein PRL antibody; Homeobox protein PBX 1 antibody; Homeobox protein PBX1 antibody; Homeobox protein PRL antibody; MGC126627 antibody; PBX 1 antibody; Pbx1 antibody; PBX1_HUMAN antibody; Pre B cell leukemia homeobox 1 antibody; Pre B cell leukemia transcription factor 1 antibody; Pre-B-cell leukemia transcription factor 1 antibody; PRL antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P40424

Immunogen

Recombinant Human Pre-B-cell leukemia transcription factor 1 protein (315-430AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:300, IF:1:50-1:200

Background

Binds the sequence 5\\\'-ATCAATCAA-3\\\'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PBX1

Research Areas

Epigenetics and Nuclear Signaling; Stem cells