PATZ1 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression| and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor| it is postulated to be a repressor of gene expression. In small round cell sarcoma| this gene is fused to EWS by a small inversion of 22q| then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human PATZ1

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

75570

synonyms

PATZ1