PASK Antibody

Size

100ug

Clone Number

Aliases

DKFZP434O051 antibody; DKFZp686P2031 antibody; hPASK antibody; KIAA0135 antibody; MGC93882 antibody; mKIAA0135 antibody; PAS domain containing serine/threonine kinase antibody; PAS domain containing serine/threonine protein kinase antibody; PAS domain-containing serine/threonine-protein kinase antibody; PAS kinase antibody; PAS serine/threonine kinase antibody; PAS-kinase antibody; Pask antibody; PASK_HUMAN antibody; PASKIN antibody; STK 37 antibody; STK37 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96RG2

Immunogen

Recombinant Human PAS domain-containing serine/threonine-protein kinase protein (482-602AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:200-1:500

Background

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PASK

Research Areas

Signal transduction