PARP2 Antibody

Size

100ug

Clone Number

Aliases

ADP ribosyltransferase like 2 antibody; ADP-ribosyltransferase diphtheria toxin-like 2 antibody; ADPRT 2 antibody; ADPRT-2 antibody; ADPRT2 antibody; ADPRTL 2 antibody; ADPRTL 3 antibody; ADPRTL2 antibody; ADPRTL3 antibody; ARTD2 antibody; hPARP 2 antibody; hPARP-2 antibody; hPARP2 antibody; NAD(+) ADP ribosyltransferase 2 antibody; NAD(+) ADP-ribosyltransferase 2 antibody; pADPRT 2 antibody; pADPRT-2 antibody; pADPRT2 antibody; PARP 2 antibody; PARP-2 antibody; PARP2 antibody; PARP2_HUMAN antibody; Poly (ADP ribose) polymerase family member 2 antibody; Poly (ADP ribosyl) transferase like 2 antibody; poly (ADP-ribose) polymerase 2 antibody; Poly [ADP ribose] synthetase 2 antibody; Poly [ADP-ribose] polymerase 2 antibody; Poly(ADP ribose) synthetase antibody; Poly[ADP-ribose] synthase 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UGN5

Immunogen

Recombinant Human Poly [ADP-ribose] polymerase 2 protein (14-149AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PARP2

Research Areas

Epigenetics and Nuclear Signaling