PAFAH1B1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

LIS 1 antibody; LIS 2 antibody; LIS-1 antibody; LIS1 antibody; LIS1_HUMAN antibody; LIS2 antibody; Lissencephaly 1 protein antibody; Lissencephaly-1 protein antibody; MDCR antibody; MDS antibody; PAF acetylhydrolase 45 kDa subunit antibody; PAF AH 45 kDa subunit antibody; PAF AH alpha antibody; PAF-AH 45 kDa subunit antibody; PAF-AH alpha antibody; PAFAH alpha antibody; PAFAH antibody; PAFAH1B1 antibody; PAFAHA antibody; Platelet activating factor acetylhydrolase 1b regulatory subunit 1 antibody; Platelet activating factor acetylhydrolase isoform Ib alpha subunit antibody; Platelet-activating factor acetylhydrolase IB subunit alpha antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P43034

Immunogen

Recombinant Human Platelet-activating factor acetylhydrolase IB subunit alpha protein (40-155AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PAFAH1B1

Research Areas

Neuroscience; Signal transduction