PADI4 Antibody

Size

100ul

Clone Number

Aliases

EC 3.5.3.15 antibody; HL 60 PAD antibody; HL-60 PAD antibody; PAD 4 antibody; PAD antibody; PADI 4 antibody; PADI 5 antibody; PADI H protein antibody; Padi4 antibody; PADI4_HUMAN antibody; PADI5 antibody; PDI 4 antibody; PDI 5 antibody; PDI4 antibody; PDI5 antibody; Peptidyl arginine deiminase type IV antibody; Peptidyl arginine deiminase type V antibody; Peptidylarginine deiminase IV antibody; Protein arginine deiminase antibody; Protein arginine deiminase type 4 antibody; Protein arginine deiminase type IV antibody; Protein-arginine deiminase type IV antibody; Protein-arginine deiminase type-4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UM07

Immunogen

Recombinant Human Protein-arginine deiminase type-4 protein (1-250AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at \\\'Arg-54\\\' (to form H1R54ci), histone H3 at \\\'Arg-2\\\', \\\'Arg-8\\\', \\\'Arg-17\\\' and/or \\\'Arg-26\\\' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at \\\'Arg-3\\\' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of \\\'Arg-54\\\' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at \\\'Arg-2142\\\', which favors its interaction with NCOA2/GRIP1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PADI4

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction