PA2G4 Antibody

Size

100ug

Clone Number

Aliases

38kDa antibody; AA672939 antibody; Cell cycle protein p38 2G4 homolog antibody; Cell cycle protein p38-2G4 homolog antibody; ErbB-3 binding protein 1 antibody; ErbB3 binding protein 1 antibody; ErbB3-binding protein 1 antibody; ErbB3-binding protein Ebp1 antibody; hG4 1 antibody; hG4-1 antibody; IRES-specific cellular trans-acting factor 45 kDa antibody; MGC81621 antibody; MGC94070 antibody; Mpp1 antibody; p38 2G4 antibody; Pa2g4 antibody; PA2G4_HUMAN antibody; Plfap antibody; Proliferation associated 2G4 antibody; Proliferation associated 2G4; 38-KD antibody; Proliferation-associated 2G4; 38kDa antibody; Proliferation-associated 2G4; a antibody; Proliferation-associated protein 1 antibody; Proliferation-associated protein 2G4 antibody; Protein p38-2G4 antibody; si:dz150i12.2 antibody; wu:fb19b11 antibody; wu:ft56d05 antibody; zgc:86732 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UQ80

Immunogen

Recombinant Human Proliferation-associated protein 2G4 protein (2-394AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PA2G4

Research Areas

Epigenetics and Nuclear Signaling