P4HB Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

P4HB antibody; PDIA1Protein disulfide-isomerase antibody; PDI antibody; EC 5.3.4.1 antibody; Prolyl 4-hydroxylase subunit beta antibody; p58 antibody

Immunogen Species

Cricetulus griseus

UniProt ID

Q8R4U2

Immunogen

Recombinant Cricetulus griseus Protein disulfide-isomerase protein (20-509AA)

Raised in

Rabbit

Species Reactivity

Cricetulus griseus

Tested Applications

Background

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

P4HB

Research Areas

Others