p38 Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals| and are involved in a wide variety of cellular processes such as proliferation| differentiation| transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs)| or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2| MEF2C| and MAX| cell cycle regulator CDC25B| and tumor suppressor p53| which suggest the roles of this kinase in stress related transcription and cell cycle regulation| as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding d

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human p38 MAPK. AA range:151-200

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

41293

synonyms

Mitogen-activated protein kinase 14; MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein