p300(Phospho Ser89) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human p300 around the phosphorylation site of Ser89. AA range:55-104

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

264144

synonyms

Histone acetyltransferase p300; EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300