p21 (Acetyl Lys154) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity| preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.|induction:By p53| mezerein (antileukemic compound) and interferon beta.|PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.|Belongs to the CDI family.|tissue specificity:Expressed in all adult human tissues| with 5-fold lower levels observed in the brain.|

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human p21 (Acetyl Lys154)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

18040

synonyms

p21 ;Acetyl Lys154; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21