p107(Phospho Thr369) Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation| as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen| with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition| both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein| it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms hav

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human RBL1 around the phosphorylation site of Thr369. AA range:335-384

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

120847

synonyms

Retinoblastoma-like protein 1; RBL1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1