ORAI1 Antibody

Size

100ug

Clone Number

Aliases

Calcium release activated calcium channel protein 1 antibody; Calcium release activated calcium modulator 1 antibody; Calcium release-activated calcium channel protein 1 antibody; CRACM 1 antibody; CRACM1 antibody; CRCM1 antibody; CRCM1_HUMAN antibody; FLJ14466 antibody; Orai 1 antibody; ORAI calcium release activated calcium modulator 1 antibody; orai1 antibody; ORAT1 antibody; Protein orai 1 antibody; Protein orai-1 antibody; TMEM 142A antibody; TMEM142A antibody; Transmembrane protein 142A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96D31

Immunogen

Recombinant Human Calcium release-activated calcium channel protein 1 protein (1-87AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ORAI1

Research Areas

Immunology; Signal transduction