OPRK1 Antibody

Size

100ul

Clone Number

Aliases

K-OR-1 antibody; Kappa opioid receptor antibody; Kappa type opioid receptor antibody; Kappa-type opioid receptor antibody; KOR 1 antibody; KOR antibody; KOR-1 antibody; Opiate receptor kappa 1 antibody; Opiate receptor; kappa 1 antibody; Opioid receptor; kappa 1 antibody; OPRK 1 antibody; OPRK antibody; OPRK_HUMAN antibody; OPRK1 antibody; Oprk2 antibody; R21 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P41145

Immunogen

Peptide sequence from Human Kappa-type opioid receptor protein (31-50AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

OPRK1

Research Areas

Neuroscience