Oct-3/4 Polyclonal Antibody

Ab type

Primary antibody

Background

POU5F1 (POU class 5 homeobox 1) encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of POU5F1 in adult tissues is associated with tumorigenesis. POU5F1 can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from Oct-3/4 at AA range: 201-250

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

38571

synonyms

POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3)