OAZ1 Antibody

Size

100ul

Clone Number

Aliases

Antizyme 1 antibody; Antizyme antibody; AZI antibody; MGC138338 antibody; OAZ 1 antibody; OAZ antibody; OAZ1 antibody; OAZ1_HUMAN antibody; ODC Az antibody; ODC-Az antibody; Ornithine decarboxylase antizyme 1 antibody; Ornithine decarboxylase antizyme antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P54368

Immunogen

Recombinant Human Ornithine decarboxylase antizyme 1 protein (1-68AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

OAZ1

Research Areas

Cancer; Metabolism; Signal transduction