OAS3 Antibody

Size

100ug

Clone Number

Aliases

(2-5'')oligo(A) synthase 3 antibody; 2 5' oligo(A) synthetase 3 antibody; 2 5'LIGO antibody; 2 5A synthetase 3 antibody; 2''-5''-oligoadenylate synthase 3 antibody; 2-5A synthase 3 antibody; MGC133260 antibody; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa antibody; OAS3 antibody; OAS3_HUMAN antibody; p100 antibody; p100 OAS antibody; p100OAS antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y6K5

Immunogen

Recombinant Human 2\'-5\'-oligoadenylate synthase 3 protein (424-565AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2\'-5\'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

OAS3

Research Areas

Epigenetics and Nuclear Signaling; Immunology