OAS1 Antibody

Size

100ug

Clone Number

Aliases

(2 5')oligo(A) synthetase 1 antibody; (2-5'')oligo(A) synthase 1 antibody; 2 5 Oligoadenylate Synthetase 1 antibody; 2 5' oligo A synthase 1 antibody; 2 5' oligo A synthetase 1 antibody; 2 5A synthase 1 antibody; 2 5A synthetase 1 antibody; 2' 5' oligo A synthetase 1 antibody; 2' 5' oligoadenylate synthetase 1 40/46kDa antibody; 2' 5' oligoadenylate synthetase 1 antibody; 2' 5' oligoisoadenylate synthetase 1 antibody; 2''-5''-oligoadenylate synthase 1 antibody; 2'5' oligo A synthetase 1 antibody; 2'5' oligoadenylate synthetase 1 antibody; 2'5' oligoisoadenylate synthetase 1 antibody; 2-5A synthase 1 antibody; E18/E16 antibody; IFI 4 antibody; IFI4 antibody; OAS 1 antibody; OAS1 antibody; OAS1_HUMAN antibody; OIAS antibody; OIASI antibody; p46/p42 OAS antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P00973

Immunogen

Recombinant Human 2\'-5\'-oligoadenylate synthase 1 protein (296-395AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2\'-5\'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

OAS1

Research Areas

Epigenetics and Nuclear Signaling