NXF3 Polyclonal Antibody

Ab type

Primary antibody

Background

NXF3 (nuclear RNA export factor 3) is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of NXF3 has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human NXF3. AA range:72-121

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

60102

synonyms

NXF3; TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3