NUDT5 Antibody

Size

100ug

Clone Number

Aliases

ADP sugar pyrophosphatase antibody; ADP-sugar pyrophosphatase antibody; hYSAH 1 antibody; hYSAH1 antibody; Nucleoside diphosphate linked moiety X motif 5 antibody; Nucleoside diphosphate linked moiety X type motif 5 antibody; Nucleoside diphosphate-linked moiety X motif 5 antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 5 antibody; Nudix motif 5 antibody; Nudix type motif 5 antibody; NUDT 5 antibody; Nudt5 antibody; NUDT5_HUMAN antibody; YSA1 antibody; YSA1H antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UKK9

Immunogen

Recombinant Human ADP-sugar pyrophosphatase protein (34-166AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500

Background

Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NUDT5

Research Areas

Epigenetics and Nuclear Signaling; Metabolism; Signal transduction